Screening molecules with anti-prion activity: kits, methods and screened molecules
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United States of America Patent
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Mar 6, 2012
Grant Date -
Aug 3, 2006
app pub date -
Oct 20, 2003
filing date -
Oct 18, 2002
priority date (Note) -
Expired
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Abstract
The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity characterized in that they comprise in combination a [PSI+], phenotype yeast, an antibiogram and an agent for purifying prions at sub-efficient doses, said yeast including the adel-14 allele of the ADE1 gene and an inactivated ERG6 gene, the screening methods, and a family of molecules with anti-prion activity isolated by the inventive screen. The invention is applicable to anti-prion agents for producing medicines in particular for treating neurodegenerative diseases involving protein aggregates.
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