Method for diagnosing cardiovascular diseases
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United States of America Patent
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Mar 6, 2012
Grant Date -
Apr 16, 2009
app pub date -
Apr 16, 2007
filing date -
Apr 24, 2006
priority date (Note) -
Expired
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Abstract
Method for diagnosing a cardiovascular disease in an individual comprising the steps of: providing a sample of an individual; determining the amount of cytokeratin-18 (CK-18) or fragments thereof and/or interleukin-1β precursor (IL-1β precursor) in the sample; comparing the amount of CK-18 or fragments thereof and/or IL-1β precursor in the sample to the amount of CK-18 or fragments thereof and/or IL-1β precursor present in a reference control of at least one individual not suffering from a cardiovascular disease; and diagnosing a cardiovascular disease if the amount of CK-18 or fragments thereof in the sample is increased in comparison to the amount of CK-18 or fragments thereof in the reference control and/or the amount of IL-1β precursor in the sample is decreased in comparison to the amount of IL-1β precursor in the reference control.
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