Method for treatment or prevention of disease associated with functional disorder of regulatory T cell
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United States of America Patent
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Mar 6, 2012
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Apr 15, 2010
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Nov 14, 2006
filing date -
Nov 14, 2005
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Abstract
The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.
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