Quantification of fusion proteins and their activity from chromosomal translocation
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United States of America Patent
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Feb 28, 2012
Grant Date -
Sep 10, 2009
app pub date -
Nov 14, 2006
filing date -
Nov 18, 2005
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Abstract
The present invention concerns the detection of gene products resulting from chromosomal translocations, including fusion proteins comprising a first and second region. In particular, the fusion proteins are identified following subjecting a sample comprising the proteins to a bead comprising an antibody to a first region, followed by subjecting the bead-antibody-fusion complex to a second antibody directed against the second region, thereby detecting the fusion protein. In particular aspects, the invention is employed to provide prognosis for an individual with cancer, to identify suitability for a particular cancer therapy, and/or to monitor response of a patient to a therapy, for example.
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