Aryl imidazoles and related compounds as C5a receptor modulators
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United States of America Patent
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Feb 21, 2012
Grant Date -
Sep 6, 2007
app pub date -
Mar 1, 2007
filing date -
Mar 29, 2002
priority date (Note) -
Expired
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Abstract
The invention provides packaged pharmaceutical preparations of Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formulawhere the variables are defined herein.Such compounds are ligands of C5a receptors. Preferred compounds of the invention act bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory and immune system disorders.
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