MALDI analysis using modified matrices with affinity groups for non-covalent binding with analytes
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United States of America Patent
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Feb 21, 2012
Grant Date -
Oct 29, 2009
app pub date -
Jun 23, 2009
filing date -
Jan 13, 2004
priority date (Note) -
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Abstract
Methods and compounds are provided to improve the desorption and ionization of analyte for mass spectrometry analysis. More specifically, it is for laser desorption/ionization mass spectrometry. The method uses photon energy absorbing molecules that can bind with analyte either temporarily or permanently to improve the desorption and ionization of analyte. The photon energy absorbing molecules can be positively charged or negatively charged.
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