Anti-idiotypic antibodies neutralizing the inhibitory activity of an inhibitory antibody directed against the C1 domain of Factor VIII
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United States of America Patent
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Feb 7, 2012
Grant Date -
Oct 22, 2009
app pub date -
Aug 23, 2007
filing date -
Feb 24, 2006
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Expired
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Abstract
The present invention is related to a monoclonal anti-idiotypic antibody directed against a Factor VIII inhibitor antibody binding to the C1 domain of Factor VIII, as well as to a cell line producing this monoclonal anti-idiotypic antibody, to the use of this monoclonal anti-idiotypic antibody as medicament, and more particularly to the use thereof for manufacturing a medicament intended for the treatment of haemophilia A.
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