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Abstract

[PROBLEMS] To provide a CGH method, in particular a CGH microarray method, enabling detection at an elevated accuracy and elevated sensitivity.[MEANS FOR SOLVING PROBLEMS] A method which comprises: (a) labeling a test genomic DNA fragment that is a cell-origin genomic DNA fragment to be tested with either a label represented by the following general formula (1) or another label represented by the general formula (2), and labeling a control genomic fragment that serves as a standard for detecting a difference from the test genomic DNA fragment with the other label; (b) hybridizing the labeled test genomic DNA fragment and the labeled control genomic DNA fragment each with a specimen nucleic acid containing a nucleic acid sequence for detecting the difference between the test genomic fragment and the control genomic fragment; and (c) detecting an amplification or deletion in the test genomic DNA fragment by using the fluorescent intensities thus obtained as an indication; and a kit for the above-described method which contains a nucleotide residue labeled with the label represented by the following general formula (1) and a nucleotide residue labeled with the label represented by the following general formula (2).

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First Claim