Methods for making and using SPR microarrays
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United States of America Patent
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Jan 10, 2012
Grant Date -
Apr 9, 2009
app pub date -
Dec 8, 2008
filing date -
Dec 6, 2005
priority date (Note) -
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Abstract
An article, process, and method for surface plasmon resonance plates are described. A substrate is covered with a thin metal film onto which a second thin metal film is deposited. The surface of the second thin metal film is converted to the metal oxide which is used to covalently bond organosilanes to the surface. Reactive organosilanes containing terminal bonding groups are arranged in a plurality of spots that are surrounded by inert organosilanes. Biomolecule attachment to the binding group is detected or measured from surface plasmon signals from the first thin metal film.
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