Metallo-β-lactamase inhibitors

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United States of America Patent

PATENT NO 8093294
APP PUB NO 20080090825A1
SERIAL NO

11889296

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Abstract

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A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

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Patent Owner(s)

Patent OwnerAddress
MEIJI SEIKA KAISHA LTDCHUO-KU 4-16 KYOBASHI 2-CHOME TOKYO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abe, Takao Sakado, JP 178 2310
Chikauchi, Ken Kawasaki, JP 6 39
Hiraiwa, Yukiko Sagamihara, JP 11 43
Ida, Mizuyo Yokohama, JP 3 9
Kudo, Toshiaki Yokohama, JP 17 220
Morinaka, Akihiro Kawasaki, JP 12 84

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