Modified leukocyte Ig-like receptor family members (LIRs) with increased affinity for class 1 MHC and their uses in modulating T-cell activation

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United States of America Patent

PATENT NO 8092807
APP PUB NO 20090208447A1
SERIAL NO

11914175

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Abstract

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or slower AND said polypeptide has at least a 45% identity and/or 55% similarity to a defined high-affinity ILT-like molecule AND said polypeptide inhibits CD8 binding to the given pMHC to a greater extent than a soluble truncated variant of Wild-Type ILT-2. Such high-affinity ILT-like molecules are useful, either alone or associated with a therapeutic agent, for the inhibition of cytotoxic T cell (CTL) responses.

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Patent Owner(s)

Patent OwnerAddress
MEDIGENE AGLOCHHAMER STR 11 PLANEGG MARTINSRIED 82152

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jakobsen, Bent Karsten Abingdon, GB 66 654
Li, Yi Abingdon, GB 917 5421
Moysey, Ruth Karen Abingdon, GB 3 0

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