Compositions and methods for therapy and diagnosis of cancer

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8088913
APP PUB NO 20090221674A1
SERIAL NO

12096216

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not produced or is produced in reduced amounts. The siRNA compounds and compositions of the invention are useful for treating diseases which require inhibition of TPTE expression for their treatment, in particular cancer pathologies. The present invention also includes methods which make possible to assess and/or prognose the metastatic behavior of a cancer disease and/or the occurrence of a relapse of cancer.

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Patent Owner(s)

Patent OwnerAddress
JOHANNES GUTENBERG-UNIVERSITAT MAINZ55128 MAINZ
GANYMED PHARMACEUTICALS AG A GERMAN CORPORATIONFREILIGRATHSTRASSE 12 MAINZ 55131

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Koslowski, Michael Mainz, DE 81 888
Sahin, Ugur Mainz, DE 331 2329
Türeci, Özlem Mainz, DE 76 516

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