Tetrahydro-naphthalene derivatives
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United States of America Patent
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Jan 3, 2012
Grant Date -
Nov 6, 2008
app pub date -
Apr 15, 2008
filing date -
Dec 6, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention relates to tetrahydro-Naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tethrahydro—Naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontienence, chronic pain, neuropathic pain, post-operative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
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