Thrombin mutant
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United States of America Patent
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Jan 3, 2012
Grant Date -
Feb 18, 2010
app pub date -
Nov 15, 2007
filing date -
Nov 15, 2006
priority date (Note) -
Expired
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Abstract
A thrombin mutant in which at least serine at position 205 among amino acids in the active center of the thrombin B chain has been replaced with another amino acid, and further at least one of the following replacements have been introduced: (I) replacement of arginine at position 89 in the B-chain with another amino acid; (II) replacement of threonine at position 69 or serine at position 22 in the B-chain with another amino acid; (III) replacement of alanine at position 200 in the B-chain with another amino acid; and (IV) replacement of lysine at position 65 in the B-chain with threonine.
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