Methods of making efavirenz and intermediates thereof
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United States of America Patent
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Dec 20, 2011
Grant Date -
Jan 20, 2011
app pub date -
Jul 20, 2009
filing date -
Jul 20, 2009
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Abstract
The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1:may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes.
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