Methods and compositions for determining the purity of and purifying chemically synthesized nucleic acids
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United States of America Patent
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Dec 13, 2011
Grant Date -
Sep 23, 2004
app pub date -
Dec 24, 2003
filing date -
Jun 29, 2001
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Abstract
An antibody microarray is described comprising a plurality of antibodies immobilized on a substrate, wherein each antibody specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having an organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are disclosed, along with cells for making such antibodies. Methods of making and using such antibody microarrays are also disclosed.
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