Phosphorylation of histone H3 at threonine 11—a novel epigenetic mark for transcriptional regulation
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United States of America Patent
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Dec 13, 2011
Grant Date -
Nov 11, 2010
app pub date -
May 27, 2008
filing date -
Jul 16, 2007
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Expired
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Abstract
The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK1 thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells.
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