Compounds of reverse turn mimetics and the use thereof (2)
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United States of America Patent
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Dec 6, 2011
Grant Date -
Sep 9, 2010
app pub date -
Oct 15, 2008
filing date -
Oct 15, 2007
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Abstract
Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic frame-work are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to the use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.
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