Oral dosage forms of water insoluble drugs and methods of making the same
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Dec 6, 2011
Grant Date -
Mar 18, 2004
app pub date -
Jul 11, 2003
filing date -
Aug 20, 2001
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
A method of making an oral dosage form of a water insoluble drug such as Saquinavir or Cyclosporine or Paclitaxel is carried out by: (a) providing a single phase working Solution comprising or consisting essentially of an active agent, water, a water-soluble polymer, and a solvent, said solvent selected from the group consisting of alcohol, acetone, and mixtures thereof; and may or may not contain a surfactant and pH of the said working solution may or may not be adjusted (b) providing particles formed from a pharmaceutically acceptable core material; (c) combining, preferably by spraying, said working solution with said particles to produce active agent-coated particles; such drug loaded particles may contain an external coat (d) drying said active agent-coated particles; and (e) forming said dried particles into an oral dosage form. Dried particles produced by the process, oral dosage forms containing such particles, and methods of treatment therewith are also described.
First Claim
Other Claims data not available
