Separation matrix having a ligand density gradient
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United States of America Patent
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Dec 6, 2011
Grant Date -
May 27, 2010
app pub date -
Jan 25, 2010
filing date -
Oct 31, 2003
priority date (Note) -
Expired
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Abstract
The present invention relates to a separation matrix comprised of ligands coupled to the surfaces of a porous support, such as one or more porous particles, wherein the ligands provide at least one chemical gradient within the support. In the most advantageous embodiment, the chemical gradient is a ligand density gradient. The invention also relates to a method of providing a separation matrix comprising ligands coupled to the surfaces of a porous support, in which method at least one ligand density gradient is provided by solvent-controlled diffusion of at least one reagent into the porous support.
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