Fusion proteins having mutated immunoglobulin hinge region
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United States of America Patent
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Nov 29, 2011
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Mar 26, 2009
app pub date -
Jul 25, 2008
filing date -
Jul 26, 2007
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Abstract
A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.
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