Selective inhibitors for cyclin-dependent kinases
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United States of America Patent
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Nov 29, 2011
Grant Date -
Oct 14, 2010
app pub date -
Dec 4, 2009
filing date -
Jun 5, 2007
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Abstract
This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.
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