Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof
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United States of America Patent
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Nov 29, 2011
Grant Date -
Oct 22, 2009
app pub date -
Jan 16, 2009
filing date -
Feb 26, 2004
priority date (Note) -
Expired
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Abstract
The present disclosure describes mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. The ELSCs of the present disclosure are capable of proliferating in an in vitro culture, maintain the potential to differentiate into cells of endoderm, mesoderm, and ectoderm lineage in culture, and are capable of forming embryoid-like bodies when placed in suspension culture. Thus, these cells possess multi-lineage differentiation potential and self-renewing capability. ELSCs may be a promising therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries.
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