Methods and compositions for delivery of growth factor to fibrous connective tissue
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United States of America Patent
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Nov 29, 2011
Grant Date -
Apr 16, 2009
app pub date -
Sep 4, 2008
filing date -
Sep 4, 2007
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Abstract
The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.
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