Trisubstituted thiazole compounds, preparations methods, pharmaceutical compositions and medicals uses thereof
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United States of America Patent
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Nov 8, 2011
Grant Date -
Dec 3, 2009
app pub date -
Aug 15, 2006
filing date -
Jun 27, 2006
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Abstract
The present invention relates to 2,4,5-trisubstituted thiazole compounds of formula (I) or all possible isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof for the inhibition of plasma PLTP activity and/or plasma CETP activity, wherein the substituents are as defined in the specification; a process for the preparation of the compounds of formula (I); a pharmaceutical composition comprising the compound of formula (I) and its use for the preparation of a medicament for treatment and/or prevention of diseases associated with the increased plasma PLTP activity and/or the increased plasma CETP activity in a mammal, such as atherosclerosis, cardiovascular diseases and peripheral vascular diseases, etc.
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