SPARC-derived tumor rejection antigenic peptides and medicaments comprising the same

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United States of America Patent

PATENT NO 8053557
APP PUB NO 20100152421A1
SERIAL NO

12304350

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Abstract

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It is an objective of the present invention to identify SPARC protein-derived peptides that are able to induce human killer T cells and helper T cells having cytotoxic activity to tumors, and to provide a means for carrying out a tumor immunotherapy of patients with various types of cancers overexpressing SPARC. The present invention provides a peptide of any of the following: (A) a peptide which consists of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide which consists of an amino acid sequence comprising a substitution or addition of one or several amino acids with respect to the peptide consisting of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has capacity to induce cytotoxic (killer) T cells.

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Patent Owner(s)

Patent OwnerAddress
ONCO THERAPY SCIENCE INCKANAGAWA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ikuta, Yoshiaki Kumamoto, JP 49 647
Nakatsuru, Shuichi Saitama, JP 63 798
Nishimura, Yasuharu Kumamoto, JP 27 150

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