Viruses with enhanced lytic potency
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United States of America Patent
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Nov 8, 2011
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app pub date -
Jan 14, 2003
filing date -
Jan 14, 2002
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Abstract
Described is a replication competent recombinant virus, being capable to replicate and having lytic capacity in target cells, the said cell being hampered in the p53 dependent apoptosis pathway, the virus including in the genome thereof, the coding sequence of at least one restoring factor functional in restoring the p53 apoptosis pathway in the said target cells, operably linked to one or more expression control sequences, functional in the said target cells, as well as the use thereof in the preparation of a medicament, in particular for suppressing uncontrolled cell growth.
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