11β-hydroxysteroid dehydrogenase type 1 active compounds

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United States of America Patent

PATENT NO 8048908
APP PUB NO 20100009968A1
SERIAL NO

12307999

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Abstract

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The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, of the general formula I. Their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSDI and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

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Patent Owner(s)

Patent OwnerAddress
HIGH POINT PHARMACEUTICALS LLC4170 MENDENHALL OAKS PARKWAY HIGH POINT NC 27265

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Andersen, Henrik Sune Lyngby, DK 89 1132
Ebdrup, Soren Roskilde, DK 44 232

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