Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
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United States of America Patent
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Oct 25, 2011
Grant Date -
Jun 19, 2008
app pub date -
Dec 11, 2007
filing date -
Dec 13, 2006
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Expired
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Abstract
The present invention discloses certain novel prodrugs of chloramphenicol or thiamphenicol, or of an analog of either, including prodrugs of pharmaceutically acceptable salts of chloramphenicol or thiamphenicol or of their analogs, including nitrogen-containing esters of both alcohol groups of such compounds. In certain embodiments these novel prodrugs are sufficiently water-soluble to serve the functions needed of a prodrug of chloramphenicol or thiamphenicol or of an analog of either. In one embodiment, a certain subclass of the compounds also possesses the hydrolytic stability needed to maintain the prodrug in solution in the subject's system until appropriate conditions exist when the prodrug can hydrolyze, releasing the active compound in question.
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