Infection and treatment of neoplasms with vesicular stomatitis virus
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United States of America Patent
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Oct 25, 2011
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app pub date -
Nov 18, 2008
filing date -
Oct 9, 1997
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Abstract
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
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