Lapachone compounds and methods of use thereof
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United States of America Patent
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Oct 18, 2011
Grant Date -
May 5, 2011
app pub date -
Jan 11, 2011
filing date -
Aug 21, 2006
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Expired
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Abstract
The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as β-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).
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