Cytoskeletal active compounds, composition and use
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United States of America Patent
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Oct 18, 2011
Grant Date -
May 27, 2010
app pub date -
Jan 28, 2010
filing date -
Mar 25, 2005
priority date (Note) -
Expired
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Abstract
The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with actin polymerization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or II, wherein said amount is effective to influence the cytoskeleton, for example by inhibiting actin polymerization.
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