Mutated HOXB4 proteins with improved stability, and methods of use thereof
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United States of America Patent
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Oct 18, 2011
Grant Date -
Dec 4, 2008
app pub date -
May 30, 2008
filing date -
Jun 1, 2007
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Abstract
A polypeptide, the amino acid sequence of which comprises a sequence as set forth in SEQ ID NO:2, including at least one mutation within the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation.
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