Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
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United States of America Patent
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Oct 4, 2011
Grant Date -
Dec 14, 2006
app pub date -
Mar 3, 2006
filing date -
Aug 18, 2000
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Abstract
There is provided a compound of Formula Iare sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIIIis any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
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