Outer membrane vesicles and uses thereof
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United States of America Patent
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Oct 4, 2011
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app pub date -
Nov 3, 2009
filing date -
Dec 23, 2003
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Abstract
The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
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