Short nucleic acid molecule-mediated modulation of Aurora B kinase expression and combinations for use in anticancer therapy
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United States of America Patent
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Sep 27, 2011
Grant Date -
Nov 11, 2010
app pub date -
Sep 25, 2009
filing date -
Jun 21, 2006
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Abstract
This invention relates to the use of short nucleic acid molecules that modulate Aurora-B kinase (AurkB) expression. The invention includes compounds, compositions and methods useful for the modulation of expression and activity of genes involved in the AurkB pathway. In one embodiment, the present invention provides short nucleic acid molecules, such as siRNA, which can be used in treating, preventing, or inhibiting cancer, and any other proliferative disease, trait or condition, which respond to a reduction in AurkB expression in a cell or tissue. Such short nucleic acid molecules can be used alone or in combination with other treatments or therapies, including short nucleic acid molecules that modulate expression of EGFR.
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