Modified VEGF-A with improved angiogenic properties
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United States of America Patent
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Sep 27, 2011
Grant Date -
Jun 21, 2007
app pub date -
Aug 15, 2006
filing date -
Aug 15, 2005
priority date (Note) -
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Abstract
The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....
- C12P:FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESI....
- A61F:FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES....
- C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF
- A61B:DIAGNOSIS; SURGERY; IDENTIFICATION
- C07K:PEPTIDES
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