Use of a chromatography substrate for reducing the amount of ADAMTS13 in a solution derived from plasma
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United States of America Patent
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Sep 27, 2011
Grant Date -
Aug 5, 2010
app pub date -
Jul 7, 2008
filing date -
Jul 5, 2007
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Expired
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Abstract
An ion-exchange chromatography support for reducing the ADAMTS13 amount present in a plasma-derived solution containing human von Willebrand factor. The support includes a large-pore, vinyl polymer-type resin bearing DEAE groups, and a buffer including trisodium citrate, sodium chloride, calcium chloride, glycine and lysine.
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