Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains
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United States of America Patent
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Sep 13, 2011
Grant Date -
Nov 29, 2007
app pub date -
Dec 4, 2006
filing date -
Dec 13, 2000
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Expired
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Abstract
The present invention provides novel polypeptides having the scaffold structure of a C-type lectin-like domain (CTLD) and a randomized loop region for specifically binding a variety of target compounds and also provides nucleic acids encoding the polypeptides. The present invention further provides combinatorial CTLD libraries, methods for constructing the libraries, and methods for screening the libraries to identify and isolate the novel CTLD polypeptides. Specifically, the invention provides libraries of nucleic acids encoding polypeptides having a scaffold CTLD with a randomized loop region, as well as nucleic acid sequences, vectors, and methods for preparing and expressing the libraries. Exemplary nucleic acids useful in the combinatorial libraries are derived from tetranectin and other proteins having a CTLD.
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