Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
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United States of America Patent
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Sep 13, 2011
Grant Date -
Jan 31, 2008
app pub date -
Aug 17, 2007
filing date -
Nov 26, 2002
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Abstract
The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
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