Recombinant toxin fragments
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United States of America Patent
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Sep 6, 2011
Grant Date -
Nov 5, 2009
app pub date -
Mar 6, 2009
filing date -
Aug 23, 1996
priority date (Note) -
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Abstract
thereby rendering the polypeptide incapable of binding to cell surface receptors that are the natural cell surface receptors to which native clostridial neurotoxin binds. Antibodies that bind to the polypeptides, and compositions comprising these antibodies, are also provided, as are DNA vaccines comprising polynucleotides that encode these polypeptides.The antigenic and antibody compositions, and the DNA vaccine compositions, can be used in methods of immunising against, or treating, clostridial neurotoxin poisoning in a subject by administering to that subject a therapeutically effective amount of the composition.
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