Photochemical internalization for delivery of molecules into the cytosol
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United States of America Patent
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Aug 30, 2011
Grant Date -
Nov 29, 2007
app pub date -
May 9, 2007
filing date -
Nov 29, 2000
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Abstract
The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosensitising agent, the cell is irradiated with light of a wavelength effective to activate the photosensitising agent and, substantially at the same time or after the irradiation, the cell is contacted with the molecule to be introduced, particularly for use in cancer treatment, gene therapy and vaccination.
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