Targeted MR imaging agents
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United States of America Patent
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Aug 23, 2011
Grant Date -
Oct 11, 2007
app pub date -
Mar 29, 2007
filing date -
Mar 29, 2006
priority date (Note) -
Expired
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Abstract
MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient concentration of the paraCEST contrast agents to obtain useful images of target tissues or organs. In addition, the image contrast may be switched on or off with a presaturation radio frequency pulse, avoiding the necessity obtaining pre-injection and post-injection images.
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