Certain chemical entities, compositions and methods
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United States of America Patent
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Aug 16, 2011
Grant Date -
Oct 1, 2009
app pub date -
Jan 23, 2009
filing date -
Feb 4, 2008
priority date (Note) -
Expired
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Abstract
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
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