Binding inhibitor of sphingosine-1-phosphate
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United States of America Patent
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Aug 9, 2011
Grant Date -
Jul 16, 2009
app pub date -
Feb 6, 2007
filing date -
Feb 6, 2006
priority date (Note) -
Expired
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Abstract
The present invention aims to provide compounds which have an inhibitory effect on the binding between S1P and its receptor Edg-1(S1P.sub.1) and which are useful for pharmaceutical purposes. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: ##STR00001## [wherein Ar represents a monocyclic heterocyclic ring containing one or two nitrogen atoms, A represents an oxygen atom or the like, Y.sup.1, Y.sup.2 and Y.sup.3 each represent a carbon atom or a nitrogen atom, R.sup.1 represents a hydrogen atom, a C.sub.1-C.sub.6 alkyl group or the like, R.sup.2 represents a C.sub.1-C.sub.6 alkyl group, a C.sub.3-C.sub.8 cycloalkyl group or the like, R.sup.3 represents a C.sub.1-C.sub.18 alkyl group or the like, R.sup.4 represents a hydrogen atom or a C.sub.1-C.sub.6 alkyl group, and R.sup.5 represents a C.sub.1-C.sub.10 alkyl group or the like].
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