Staphylococcus protein A domain mutants that bind to TNF-α
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United States of America Patent
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Aug 9, 2011
Grant Date -
Dec 10, 2009
app pub date -
Mar 1, 2006
filing date -
Mar 1, 2005
priority date (Note) -
Expired
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Abstract
A TNF-α binding polypeptide is provided, which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, expression vector comprising the nucleic acid, and host cell comprising the expression vector are also provided. Also provided are methods comprising a step of affinity separation or detection, in which step a polypeptide according to the invention is used. Such methods may be used for reducing the content of TNF-α in a body fluid.
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