Protein formulation
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United States of America Patent
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Jul 26, 2011
Issued Date -
N/A
app pub date -
Dec 12, 2005
filing date -
Dec 10, 2004
priority date (Note) -
Expired
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Abstract
The present invention relates to a new and improved low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, intended to be used as therapeutic, as propylacetic and/or as cosmetic agent. In the present invention, said active enamel substance is incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or cell-occlusive. The active enamel substance can be incorporated into the polymeric matrix so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion. Comprised in the invention is thus in particular a new pharmaceutical and/or cosmetic formulation of an active enamel substance at a lower total concentration within the formulation, wherein a spatial and/or selective regulation of release of said active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity.
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