Antibody specificity transfer using minimal essential binding determinants
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United States of America Patent
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Jul 19, 2011
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Jan 20, 2005
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Jan 20, 2004
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Abstract
The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, e.g., in humanization procedures. The invention also provides libraries and antibodies made in accordance with the methods.
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