Method of preparing polyepitope chimeric gene vaccine
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United States of America Patent
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Jul 19, 2011
Grant Date -
Jan 11, 2007
app pub date -
Aug 1, 2003
filing date -
Aug 1, 2003
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Abstract
The invention relates to a method for preparing polyepitope chimeric gene vaccines, designated as Epitopes Assemble Library Immunization (EALI). It involves the construction of expression libraries of polyepitope chimeric genes with different sizes and lengths using gene shuffling and random assembly so as to screen polyepitope chimeric gene vaccines. Immunization of the body with the gene libraries of the invention results in the induction of high level of specific antibodies and specific types of cytokines, and protection on the body.
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