Pharmaceutical compositions and methods for delivering nucleic acids into cells
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United States of America Patent
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Jul 19, 2011
Grant Date -
Jun 25, 2009
app pub date -
Nov 24, 2008
filing date -
Nov 26, 2007
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Expired
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Abstract
The present invention relates to methods of delivering nucleic acids into cells using a nucleic acid binding molecule containing a multimeric or spacer-incorporated protein transduction domain (PTD). The invention also relates to novel compositions that contain a nucleic acid complexed or conjugated with a nucleic acid binding molecule. The nucleic acid binding molecule may contain a multimeric or spacer-incorporated PTD, and may further contain a nucleic acid binding region. The nucleic acid complexes or conjugations of the present invention may be employed to inhibit expression of a target gene, and/or determine the function of a target gene.
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